Recent Publications
Paliwal N, Tutino VM, Shallwani H, Beecher JS, Damiano J, Shakir HJ, Atwal GS, Fennell VS, Natarajan SK, Levy EI, Siddiqui AH, Davies JM, Meng H. “ Ostium Ratio and Neck Ratio Could Predict the Outcome of Sidewall Intracranial Aneurysms Treated with Flow Diverters”, AJNR Am J Neuroradiol (epub January 24, 2019). PMID: 306792216
Tutino VM, Poppenberg KE, Li L, Shallwani H, Jiang K, Jarvis JN, Sun Y, Snyder KV, Levy EI, Siddiqui AH, Kolega J, Meng H. “ Biomarkers from Circulating Neutrophil Transcriptomes Have Potential To Detect Unruptured Intracranial Aneurysms”, J Transl Med. 2018 Dec 28;16(1):373. PMID: 30593281
Paliwal N, Jaiswal P, Tutino VM, Shallwani H, Davies JM, Siddiqui AH, Rai R, Meng H. “ Outcome prediction of intracranial aneurysm treatment by flow diverters using machine learning”, Neurosurg Focus 45 (5):E7, 2018. PMID: 30453461
Rajabzadeh-Oghaz H, Varble N, Shallwani H, Tutino VM, Mowla A, Shakir HJ, Vakharia K, Atwal GS, Siddiqui AH, Davies JM, Meng H.“ Computer-Assisted 3D Morphology Evaluation of Intracranial Aneurysms”, World Neurosurg. 2018 Nov;119:e541-e550. PMID: 30075262
Varble N, Tutino VM, Yu J, Sonig A, Siddiqui AH, Davies JM, Meng H. “ Shared and Distinct Rupture Discriminants of Small and Large Intracranial Aneurysms”, Stroke, 49(4):856-864, 2018. PMID: 29535267
Varble N, Kono K, Rajabzadeh-Oghaz H, Meng H. “ Rupture resemblance models may correlate to growth rates of intracranial aneurysms: preliminary results”, World Neurosurg. 2018 Feb;110:e794-e805. PMID: 29180083
Tutino VM, Poppenberg KE, Jiang K, Jarvis JN, Sun Y, Sonig A, Siddiqui AH, Snyder KV, Levy EI, Kolega J, Meng H. “ Circulating neutrophil transcriptome may reveal intracranial aneurysm signature”, PLoS ONE, 2018 Jan 17;13(1):e0191407. PMID: 29342213
Paliwal N, Damiano RJ, Varble NA, Tutino VM, Dou Z, Siddiqui AH, Meng H. “ Methodology for CFD Validation for Medical Use: Application to Intracranial Aneurysm”, J Biomech Eng. 2017 Dec 1;139(12). PMID: 28857116
Xiang J, Varble N, Davies JM, Rai AT, Kono K, Sugiyiama SI, Binning MJ, Tawk RG, Choi H, Ringer AJ, Snyder KV, Levy EI, Hopkins LN, Siddiqui AH, Meng H. “ Initial Clinical Experience with AView―A Clinical Computational Platform for Intracranial Aneurysm Morphology, Hemodynamics, and Treatment Management”, World Neurosurg 2017 Dec; 108:534-542. PMID: 28919570
Varble N, Rajabzdeh-Oghaz H, Wang J, Siddiqui A, Meng H, Mowla A. “ Differences in Morphological and Hemodynamic Characteristics for “PHASES-Based” Intracranial Aneurysm Locations”, AJNR Am J Neuroradiol 2017 Nov;38(11):2105-2110. PMID: 28912279
Varble N, Trylesinski G, Xiang J, Snyder K, Meng H. “ Identification of vortex structures in a cohort of 204 intracranial aneurysms”, J R Soc Interface. 2017 May; 14(130). pii: 20170021. PMID: 28539480
Damiano RJ, Tutino VM, Paliwal N, Ma D, Davies JM, Siddiqui AH, Meng H. “ Compacting a Single Flow Diverter versus Overlapping Flow Diverters for Intracranial Aneurysms: A Computational Study”, AJNR Am J Neuroradiol. 2017; 38(3):603-610. PMID: 28057633
Varble N, Xiang J, Lin N, Levy E, Meng H. “ Flow Instability Detected by High-Resolution CFD in Fifty-Six Middle Cerebral Artery Aneurysms”, J Biomechanical Eng. 2016 Jun 1;138(6). PMID: 27109451
Tutino VM, Liaw N, Spernyak J, Ionita C, Siddiqui AH, Kolega J, Meng H. “ Assessment of Vascular Geometry for Bilateral Carotid Artery Ligation to Induce Early Basilar Terminus Aneurysmal Remodeling in Rats”, Current Neurovascular Research 2016;13(1):82-92. PMID: 26503026
Rajabzadeh-Oghaz H, Varble N, Davies JM, Mowla A, Shakir HJ, Sonig A, Shallwani H, Snyder KV, Levy EI, Siddiqui AH, Meng H. “ Computer-Assisted Adjuncts for Aneurysmal Morphologic Assessment: Toward More Precise and Accurate Approaches”, Proc SPIE Int Soc Opt Eng. 2017. PMID: 28867867
Paliwal N, Damiano RJ, Davies JM, Siddiqui AH, Meng H. “ Association between Hemodynamic Modifications and Clinical Outcome of Intracranial Aneurysms Treated Using Flow Diverters”, Proc SPIE Int Soc Opt Eng 10135, Medical Imaging 2017. PMID: 28515570
Paliwal, N., Yu, H., Xu, J., Xiang, J., Siddiqui, A.H., Yang, X., Li, H. & Meng, H. 2016 Virtual stenting workflow with vessel-specific initialization and adaptive expansion for neurovascular stents and flow diverters . Computer methods in biomechanics and biomedical engineering 19, 1423-1431
Damiano, R., Tutino, V., Paliwal, N., Ma, D., Davies, J., Siddiqui, A. & Meng, H. 2017 Compacting a Single Flow Diverter versus Overlapping Flow Diverters for Intracranial Aneurysms: A Computational Study. American Journal of Neuroradiology.
Varble, N., Xiang, J., Lin, N., Levy, E. & Meng, H. 2016 Flow instability detected by high-resolution computational fluid dynamics in fifty-six middle cerebral artery aneurysms. Journal of biomechanical engineering 138, 061009.
Xiang, J., Antiga, L., Varble, N., Snyder, K.V., Levy, E.I., Siddiqui, A.H. & Meng, H. 2016 AView: An Image-based Clinical Computational Tool for Intracranial Aneurysm Flow Visualization and Clinical Management. Annals of biomedical engineering 44 , 1085-1096. (doi:10.1007/s10439-015-1363-y).
Matthew Tutino, V., Liaw, N., Andrew Spernyak, J., Nicolae Ionita, C., Hussain Siddiqui, A., Kolega, J. & Meng, H. 2016 Assessment of vascular geometry for bilateral carotid artery ligation to induce early basilar terminus aneurysmal remodeling in rats.
Current neurovascular research 13 , 82-92
Xiang, J., Damiano, R.J., Lin, N., Snyder, K.V., Siddiqui, A.H., Levy, E.I. & Meng, H. 2015 High-fidelity virtual stenting: modeling of flow diverter deployment for hemodynamic characterization of complex intracranial aneurysms. Journal of neurosurgery, 1-9. (doi:10.3171/2014.11.JNS14497).
Damiano, R.J., Ma, D., Xiang, J., Siddiqui, A.H., Snyder, K.V. & Meng, H. 2015 Finite element modeling of endovascular coiling and flow diversion enables hemodynamic prediction of complex treatment strategies for intracranial aneurysm. Journal of biomechanics . (doi: http://dx.doi.org/10.1016/j.jbiomech.2015.06.018 ). Xiang J, Antiga L, Varble N, Snyder KV, Levy EI, Siddiqui AH, Meng H, “ AView: An Image-based Clinical Computational Tool for Intracranial Aneurysm Flow Visualization and Clinical Management”, Ann Biomed Eng, [Epub ahead of print], 2015 Jun 23. PMID: 26101034 Damiano R, Ma D, Xiang J, Snyder KV, Meng H, “ Finite Element Modeling of Endovascular Intervention Enables Hemodynamic Prediction of Complex Treatment Strategies of Coiling and Flow Diversion”, J Biomechanics, 2015 Jun 27. Xiang J, Damiano R, Lin N, Snyder KV, Siddiqui AH, Levy EI, Meng H, “ High-fidelity virtual stenting: modeling of flow diverter deployment for hemodynamic characterization of complex intracranial aneurysms”, Journal of Neurosurgery, [Epub ahead of print], 2015 Jun 19:1-19. PMID: 26090829 (Xiang and Damiano contributed equally to this work) Xiang J, Damiano R, Lin N, Snyder KV, Levy EI, Siddiqui AH, Meng H, “ Flow diverters - One device does not fit all. Response”, Journal of Neurosurgery, [Epub ahead of print], 2015 Jun 19:1-3. PMID: 26090837 Xiang J, Yu J, Snyder K, Levy EI, Siddiqui AH, Meng H, “ Hemodynamic-morphological discriminant models for intracranial aneurysm rupture remain stable with increasing sample size”, J Neurointerv Surg, [Epub ahead of print], 2014 Dec 8. PMID: 25488922 Xiang J, Siddiqui AH, Meng H, “ The Effect of Inlet Waveform Boundary Conditions in Computational Hemodynamics of Intracranial Aneurysms”, Journal of Biomechanics, 47(16):3882-90, 2014. PMID: 25446264 Xiang J, Yu J, Choi H, Fox Dolan J, Snyder K, Levy EI, Siddiqui AH, Meng H, “ Rupture Resemblance Scale (RRS)?Toward Risk Stratification of Unruptured Intracranial Aneurysms Using Hemodynamic-Morphologic Discriminants”, J Neurointerv Surg, 7(7):490-5, 2015. PMID: 24811740 Xiang J, Ma D, Snyder K, Levy EI, Siddiqui AH, Meng, H, “ Increasing Flow Diversion for Cerebral Aneurysm Treatment Using a Single Flow Diverter”, Neurosurgery, 75(3):286-94, 2014. PMID: 24867201 Ma D, Xiang J, Choi H, Natarajan S, Dumont TM, Siddiqui AH, Meng H, “ Enhanced Aneurysm Flow Diversion using Dynamic Push-Pull Technique: An Experimental and Modeling Study”, AJNR Am J Neuroradiol, 35(9):1779-85, 2014. PMID: 24763414 Xiang J, Tutino V, Snyder K, Meng H, “ CFD: Computational Fluid Dynamics or Confounding Factor Dissemination? The Role of Hemodynamics in Intracranial Aneurysm Rupture Risk Assessment”, AJNR Am J Neuroradiol, [Epub ahead of print], 2013 Sep 12. PMID: 24029393 Liu J, Xiang J, Ma D, Zhang Y, Wang Y, Li H, Meng H, “ Morphologic and Hemodynamic analysis of paraclinoid aneurysms: ruptured vs unruptured”, J Neurointerv Surg,6(9):658-63, 2014. PMID: 23598838 Meng H, Tutino VM, Xiang J, Siddiqui A, “High WSS or Low WSS? Complex Interactions of Hemodynamics with Intracranial Aneurysm Initiation, Growth, and Rupture: Toward a Unifying Hypothesis”, AJNR Am J Neuroradiol, 35(7):1254-62, 2014. PMID: 23598838 Dolan JM, Kolega J, Meng H, “High Wall Shear Stress and Spatial Gradients in Vascular Pathology: A Review”, Annals of Biomedical Eng, 41(7):1411-27, 2013. PMID: 23229281 Ma D, Dargush GF, Natarajan SK, Levy EI, Siddiqui AH, Meng H, “Computer modeling of deployment and mechanical expansion of neurovascular flow diverter in patient-specific intracranial aneurysms”, J Biomech., 45: 2256-63, 2012. PMID: 22818662 Xiang J, Tremmel M, Kolega J, Levy EI, Natarajan SK, Meng H, “Newtonian viscosity model could overestimate wall shear stress in intracranial aneurysm domes and underestimate rupture risk”, J Neurointerv Surg., 4: 351-7, 2012. PMID: 21990529 Kolega J, Gao L, Mandelbaum M, Natarajan SK, Mocco J, Siddiqui AH, Meng H, "Cellular and molecular responses of the basilar terminus to hemodynamics during intracranial aneurysm initiation in a rabbit model", J Vasc Res., 48: 429-442, 2011. PMID: 21625176 Dolan JM, Meng H, Sigh S, Paluck RA, Kolega J, "High Fluid Shear Stress and Spatial Shear Stress Gradients Affect Endothelial Proliferation, Survival, and Alignment", Annals of Biomedical Eng, 39: 1620, 2011. PMID: 21312062 Xiang J, Natarajan SK, Tremmel M, Ma D, Mocco J, Hopkins LN, Siddiqui AH, Levy EI and Meng H, "Hemodynamic Morphological Discriminants for Intracranial Aneurysms Rupture", Stroke, 42:144-152, 2011. PMID: 21106956 Meng H, Metaxa E, Gao L, Liaw N, Natarajan SK, Swartz DD, Siddiqui AH, Kolega J, Mocco J, "Progressive Aneurysm Development Following Hemodynamic Insult", J Neurosurg., 114: 1095-1103, 2011. PMID: 20950086 Tanweer O, Metaxa E, Liaw N, Sternberg DS, Siddiqui AH, Kolega J, Meng H, "Inhibition of Stretch-activated Ion Channels on Endothelial Cells Disrupts Nitric Oxide-mediated Arterial Outward Remodeling", J Biorheology, 24:77-83, 2010. Tremmel M, Xiang J, Natarajan SK, Hopkins LN, Siddiqui AH, Levy EI, Meng H, "Alteration of Intra-aneurysmal Hemodynamics for Flow Diversion Using Enterprise and Vision Stents", World Neurosurgery, 74:306-315, 2010. PMID: 21197155 Metaxa E, Tremmel M, Natarajan SK, Xiang J, Paluch RA, Mandelbaum M, Siddiqui AH, Kolega J, Mocco J, Meng H, "Characterization of Critical Hemodynamics Contributing to Aneurysmal Remodeling at the Basilar Terminus in a Rabbit Model", Stroke, 41:1774-1782, 2010 (Featured on Cover of Stroke, August 2010 issue). PMID: 20595660 Tremmel M, Xiang J, Hoi Y, Kolega J, Siddiqui AH, Mocco J, Meng HNeurosurgery, "Mapping Vascular Response to In Vivo Hemodynamics: Application to Increased Flow at the Basilar Terminus", Biomech Model Mechanobiol., 9: 421-434, 2010. PMID: 20054605 Rahman M, Smietana J, Hauck EF, Hoh B, Hopkins LN, Siddiqui AH, Levy EI, Meng H, Mocco J, "Size Ratio Correlates with Intracranial Aneurysm Rupture Status: A Prospective Study", Am Stroke, 41:916-920, 2010. PMID: 20378866 Meng H, Natarajan SK, Gao L, Ionita C, Kolega J, Mocco J, Siddiqui AH, "Aneurysmal Changes at the Basilar Terminus in the Rabbit Elastase Aneurysm Model", AJNR Am J Neuroradiol, 31:300-3. 2010. PMID: 20053800 Ma D, Tremmel M, Paluch R, Levy EI, Meng H, Mocco J, "Size Ratio for Clinical Assessment of Intracranial Aneurysm Rupture Risk", Neurol Res., 32: 482-486, 2010. PMID: 20092677 de Jong J, Salazar J, Woodward SH, Collins LR, Meng H, "Measurement of inertial particle clustering and relative velocity statistics in isotropic turbulence using holographic imaging", Int J Multiphase Flow , 36:324-332, 2010.