Optimal Staging

• Apply precision model to optimize choice of intermediate in staged insertion

  • how best to define UW?

• Overall variance is the sum of variances of all stages

• Choose W:

  • minimize
  • subject to
  • obtain
  • ? j/?i: order of unity

• Heuristic: D(DS) = 0

  • equal entropy difference
  • compare to unjustified rule-of-thumb equal free-energy difference D(DA/k) = 0
  • new rule greatly improves the precision

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