Asymmetry of the Inaccuracy 1.
The opposite tendency of the insertion/deletion inaccuracy leads to statements like these
- “The forward and reverse [inaccuracy] should be of the same magnitude and opposite sign” J. Phys. Chem., 98, 1487-1493,1999
- “The free energy change was taken as the average of the forward and reverse free energies.” J Comp. Chem., 20, 499-510, 1999
Remember the asymmetry of the hard-sphere insertion/deletion methods
- for insertion, e-bm is zero until a non-overlap is completed
- for deletion e+bm is always unity
- averaging the insertion and deletion m’s would be bad