Deletion Method
The FEP formula may be used also with the roles of the reference and target system reversed
- sample the 1 system, evaluate properties of 0 system
Consider application to hard spheres
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- e-but is infinity for overlap, 0 otherwise
- but overlaps are never sampled
- true average is product of 0 ? ?
technically, formula is correct
- in practice simulation average is always zero
method is flawed in application
many times the flaw with deletion is not as obvious as this