Dr. P. Alexandridis
Assistant Professor of Chemical Engineering
Department of Chemical Engineering
University at Buffalo (UB)
The State University of New York (SUNY)
tel: (716) 645-2911 ext. 2210
fax: (716) 645-3822
Ph.D. (Chemical Engineering), Massachusetts Institute of Technology,
M.S. (Chemical Engineering Practice), Massachusetts Institute
of Technology, 1990
Dipl.-Eng. (Chemical Engineering), National Technical University,
Postdoctoral Fellow (Polymer Physical Chemistry), Lund University,
Areas of Expertise: block copolymers,
amphiphilic polymers, surfactants, resins,
polymer gels (physically or chemically cross-linked), structured
fluids, lyotropic liquid crystals,
self-assembly, phase behavior, microstucture, micellization,
microemulsions, emulsions, micellar kinetics, polymer-surfactant
recognition, controlled release, rheology, wetting, adhesion.
My research aims in elucidating the interrelations between (i)
the molecular characteristics of
amphiphilic molecules (such as block copolymers and surfactants),
(ii) the structure of organized
assemblies formed by amphiphiles, and (iii) the functional properties
of such assemblies.
Amphiphile self-assemblies can be utilized for the development
of novel materials and
processes of interest to chemical, bio-, and materials engineering.
Amphiphilic (i.e., containing both hydrophilic and hydrophobic
parts) molecules, such
as surfactants, lipids, copolymers, and proteins, find widespread
use in the chemical,
pharmaceutical, and food industry, because of their unique ability
to self-assemble and modify
the surface/interfacial properties, thus either enhancing compatibility
or imposing partition. The
self-assembly is governed by (tuneable) molecular- and colloidal-level
interactions and its
control is crucial for tailoring the properties of systems where
amphiphiles are present.
Ongoing Research Projects
"Phase behavior and microstructure of block copolymers in selective
"Effects of cosolvents and cosolutes on self-assembly of amphiphiles
(surfactants or polymers)"
"Effect of shear on microstructure of ordered block copolymers"
"Solvent penetration and structure formation in the dissolution
of block copolymers"
"Controlled release from hydrogels based on self-assembled amphiphilic
"Interactions between cyclodextrins and hydrophobically modified
Experimental Techniques: small-angle X-ray scattering (SAXS),
scattering (SANS), static light scattering (LS), dynamic light
scattering (DLS), UV-vis
spectroscopy, fluorescence spectroscopy, nuclear magnetic resonance
differential scanning calorimetry (DSC), isothermal titration
calorimetry (ITC), surface
tensiometry, contact angle measurements, rheology (dynamic
mechanical spectroscopy), liquid
chromatography (LC), temperature-jump & stopped flow fast-reaction
scanning electron microscopy (SEM), electron spectroscopy for
chemical analysis (ESCA).
Theoretical Techniques: interfacial phenomena, intermolecular
forces, self-assembly theory,
polymer thermodynamics, lattice mean-field models, scaling theory,
National Science Foundation (1999-2003)
Petroleum Research Fund (1998-2001)
The Dow Chemical Co. (2000-2001)
Xerox Foundation (1998-2001)
Landmark Direct Corp. (2000)
Technicor, Inc. (1999-2000)
Protective Closures Co., Inc. (1999)
Bausch & Lomb (1998-1999)
FlexOvit USA, Inc. (1998-1999)
"Solvent-Regulated Ordering in Block Copolymers"
Opin. Colloid Interface Sci.
1999, 4, 130-139. (with R. J. Spontak)
"Poly(ethylene oxide)-Poly(propylene oxide)
Block Copolymer Surfactants" Curr. Opin.
Colloid Interface Sci. 1997, 2, 478-489.
"Amphiphilic Copolymers and their Applications"
Opin. Colloid Interface Sci.
1996, 1, 490-501.
"Block Copolymer Micelles (An Overview)" In
Salamone, J. C. (Ed.); CRC Press: Boca Raton, FL, 1996;
pp. 743-754. (with T. A. Hatton)
structural polymorphism of
block copolymers in selective solvents
"A Record Nine Different Phases (Four
Cubic, Two Hexagonal, and One Lamellar
Lyotropic Liquid Crystalline, and Two Micellar Solutions) in
a Ternary Isothermal System of an
Amphiphilic Block Copolymer and Selective Solvents (Water and
2627-2638. (with U. Olsson and B. Lindman)
"Modification of the Microstructure in Poloxamer
Block Copolymer - Water - 'Oil' Systems
by Varying the Copolymer Composition and the "Oil" Type: A Small
Angle X-ray Scattering and
Deuterium NMR Investigation" J. Phys. Chem. B 1998,
1149-1158. (with P. Holmqvist
and B. Lindman)
"Structural Polymorphism of Amphiphilic
Copolymers: Six Lyotropic Liquid Crystalline and
Two Solution Phases in a Polyoxybutylene-b-Polyoxyethylene -
Water - Xylene System"
Langmuir 1997, 13, 23-34. (with U. Olsson
and B. Lindman)
"Lyotropic Liquid Crystallinity in Amphiphilic
Block Copolymers: Temperature Effects on
Phase Behavior and Structure of Poly(ethylene oxide)-b-Poly(propylene
(ethylene oxide) Copolymers of Different Compositions" Langmuir
(with D. Zhou and A. Khan)
cosolvent effect on block
Investigation of Polyether Block Copolymer Micelle Structure in Mixed Solvents
Water and Formamide, Ethanol, or Glycerol"
5574-5587. (with L. Yang)
"Effect of Glycols on
the Self-Assembly of Amphiphilic Block Copolymers in Water. II.
Glycol Location in the Microstructure"
3676-3689. (with R. Ivanova and
of Poly(ethylene oxide)/Poly(propylene oxide) Block Copolymers
in Non-Aqueous Polar Solvents" Macromolecules
Calorimetry Investigation on the Effect of Salts on Aqueous Solution
Properties of an Amphiphilic Block Copolymer(Poloxamer)"
(with J. F. Holzwarth)
block copolymer micellization
in aqueous solutions
"Dynamics of Micro- and Macrophase Separation of
Amphiphilic Block-Copolymers in Aqueous
Solution” Macromolecules 1999, 32(17), 5539-5551.
(with M. Kositza, C. Bohne, T. A. Hatton,
and J. F. Holzwarth)
"Effect of Block Size and Sequence on the
Micellization of ABC Triblock Methacrylic
Polyampholytes" Macromolecules 1995, 28,
8604-8611. (with W.-Y. Chen, C.-K. Su,
C. S. Patrickios, W. R. Hertler, and T. A. Hatton)
"Temperature Effects on Structural Properties
of Pluronic P104 and F108 PEO-PPO-PEO
Block Copolymer Solutions" Langmuir 1995,
1468-1476. (with T. Nivaggioli and T. A. Hatton)
"Micellization of Poly(ethylene oxide)-Poly(propylene
oxide)-Poly(ethylene oxide) Triblock
Copolymers in Aqueous Solutions: Thermodynamics of Copolymer
Macromolecules 1994, 27, 2414-2425. (with
J. F. Holzwarth and T. A. Hatton)
solubilization - microemulsions
- water-in-oil (reverse) micelles
"13C NMR Evidence on Amphiphile Lifetime in Reverse (Water-in-Oil)
by a Poloxamer Block Copolymer" J. Colloid Interface Sci.
357-360. (with P. C. A.
"Reverse Micelle Formation and Water Solubilization by
Copolymers in Organic Solvent" J. Phys. Chem. B 1997,
8103-8111. (with K. Andersson)
"Solubilization in Amphiphilic Copolymer Solutions"
Sci. Ser. 1995, 55,191-235.
(with P. N. Hurter and T. A. Hatton)
"Thermodynamics of Droplet Clustering in Percolating AOT
J. Phys. Chem. 1995, 99, 8222-8232. (with
J. F. Holzwarth and T. A. Hatton)
· Mr. Brian M. Trapp: Surface Property
Modification via Surface Active Displacement Solutions
to Improve Semi-Volatile Organic and High
Molecular Weight Compound Bioremediation,
Master of Engineering Project, July 1999.
· Ms. Yining Lin: Surface Characterization
of Plain Paper as Applied to Paper-Ink Interactions in
Ink-Jet Printing, Master of Science Thesis,
· Mr. Aristides Docoslis: Kinetics
of Curing and Dissolution of Phenolic Resins in the Manufacture
and Recycling of Fiberglass Composites,
Master of Science Thesis, August 1999.
· Ms. Sungsook Ahn: Phase Behavior
and Microstructure of Crosslinked Polydimethylsiloxane
Hydrogels, Master of Science Thesis, January
· Mr. Jiong Yu: Cross-linking of
Amphiphile Self-Assemblies for the Preparation of Nanoporous
Materials, Master of Science Thesis, January
· Mr. Suddha S. Talukdar: Modelling
of Drug Release from Polymer Matrix, Master of Science
Thesis, May 2000.
· Ms. Lin Yang: Microstructure,
Dynamics, and Applications of Solvated Amphiphilic Block
Copolymers, Doctor of Philosophy Dissertation,
· Ms. Sungsook Ahn: Gel Formation
in Solutions of Associating Polymers and Surfactants,
Doctor of Philosophy Dissertation, January
· Ms. Yining Lin: Solution and Adsorption
Properties of Polymeric Amphiphiles, Doctor of
Philosophy Dissertation, January 2001 (expected).
· Mr. Bradley Songui: Cosolvent
Effects on Polymeric Amphiphile Micelle Structure,
Master of Science, May 2001 (expected).
Honors & Awards
Faculty Early Career Development Award (CAREER), National Science
Member of the Editorial Committee, Journal of Dispersion Science
and Technology (2000)
Listed in Who's Who in Plastics and Polymers (2000)
Dow Outstanding New Faculty Award, American Society for Engineering
Outstanding Scholarship in Vacuum Science and Technology, American
Vacuum Society (1998)
Riefler Award, University at Buffalo (1997, 1998, 1999)
Article featured on the cover of Langmuir, the ACS Journal of
Surfaces and Colloids (1998)
Member, New York Academy of Sciences (1996)
Postdoctoral Fellow, Swedish Natural Science Research Council
Fulbright Scholar (1989-1994)
Outstanding Presentation Award, American Oil Chemists' Society
Member, Sigma Xi Scientific Research Society (1993)
Keith and Helen Rumbel Fellow (1992)
Haas Family Fellow (1990)
Atlantic-Richfield Foundation Fellow (1989)
Zografaki Prize (1989)
Registered Professional Engineer (Greece) (2/91)
Member, American Institute of Chemical Engineers (AIChE)
Member, American Chemical Society (ACS)
Member, ACS Division of Polymer Chemistry
Member, ACS Division of Polymeric Materials: Science and Engineering
Member, ACS Division of Colloid and Surface Chemistry
Member, Society of Plastics Engineers (SPE)
Member, Controlled Release Society (CRS)
Member, American Association for the Advancement of Science (AAAS)
Member, American Society for Engineering Education (ASEE)
Reviewer for: Macromolecules, Journal of Polymer Science B, Langmuir,
Journal of Colloid and
Interface Science, The Journal of Physical Chemistry, Colloid
and Polymer Science, ACS
Symposium Series, The Journal of Adhesion, Biotechnology and
Bioengineering, Nature, Polymer,
Journal of Rheology, Langmuir, Journal of Colloid and Interface
Science, Colloids and Surfaces A,
Industrial and Engineering Chemistry Research, Biotechnology
and Bioengineering, Biochemical
Engineering Journal, International Journal of Pharmaceutics,
ACS Symposium Series, The
Journal of Adhesion, proposals for the Petroleum Research Fund,
the National Science Foundation,
and the Center For Neutron Research (NCRC) at the National Institute
of Standards and Technology.
Co-organizer and Chair, Symposium on Dynamics of Self-Organization
of Amphiphiles and Colloids,
2001 Spring ACS Meeting.
Organizer and Chair, "Self-Assembly in Solution" sessions, 1997,
1998, 1999, 2000 and 2001
Annual AIChE Meetings.
Organizer and Chair, "Drug Delivery" sessions, 1999 Annual AIChE
Organizer and Chair, "Partitioning and Extraction" sessions,
International Conference on
Bioseparation Engineering, Nikko, Japan, July 1999.
Co-organizer, UB Chemical Engineering Graduate Research Symposium,
Member of the Undergraduate Committee, UB Dept. of Chemical Engineering
Member of the Faculty Search Committee, UB Dept. of Chemical
Member of the Safety Committee, UB Dept. of Chemical Engineering
Introduction to Chemical Engineering
(CE212) (fall 1997, 1998, 1999, 2000)
The course provides
an introduction to chemical engineering concepts. Material and
energy balances on chemical processes, phenomena that govern
phase equilibria are covered.
The students gain an appreciation of the engineering approach
to solving problems.
Introduction to Polymers (CE435)
(spring 1999, 2000)
Synthesis of polymers.
Solution properties, thermodynamics, and molecular weight
determination. Solid-state properties of polymers.
Viscoelasticity and rubber elasticity.
Polymer processing and rheology. Polymer additives, blends
Degradation, stability, and environmental issues. Commodity
thermoplastics and fibers.
Network polymers: elastomers and thermosets. Engineering
and specialty polymers.
Polymer Physical Chemistry
(CE537) (spring 1997, 1999, 2001)
of polymers and techniques for the characterization of polymer
molecular weight and size. Statistical thermodynamics of
polymer solutions, phase equilibria
in polymer systems. Polymers in the amorphous, crystalline,
or rubber state. Cross-linked
polymers and rubber elasticity.
Colloid and Surface Phenomena
(CE457/527) (spring 1998, 2000)
surface forces: dispersion, ionic, Lewis acid-base.Surface
thermodynamics: surface tension, contact angle, electrical aspects.
stability, aggregation kinetics. Association colloids: micelles,
Detergency & emulsions. Surface films. Polymers in colloid
systems. Characterization of
colloids and surfaces.
List of Scientific
List of Lectures